Dosing
- SAM-e can be beneficial at many different dosages. It’s important to note, however, that SAM-e is a nutritional supplement that should be taken daily to maintain SAM-e levels in the body.
- Whenever possible, SAM-e should be taken on an empty stomach to prevent disturbance and maximize absorption. Lower doses (i.e., 400-600 mg/day), may be taken at once, half an hour before breakfast. Higher doses should be split, with the remainder taken one-half to one hour before lunch.
- For Mood Health: When SAM-e is indicated as a mood supplement, 400-600 mg/day may be sufficient as a maintenance dose. If no effect is seen at this supplementation level, dosage may be titrated up to 1600 mg/day, increasing the dose by 200 mg every 3-7 days. Patients with anxiety disorder should start at lower doses, eg, 100 mg/day, and titrate up in smaller increments. It should be noted that patients with bipolar disorder should be monitored carefully, and may require additional mood stabilizers to prevent hypomania.
- For Liver Health: When recommending SAM-e to combat liver toxicity, a higher starting dose is indicated, eg, 1200 mg/day.
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