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Q: Can I take St. John's Wort and SAM-e together?

SAM-e and St. John's Wort are not to be taken together. SAM-e is different from St. John’s Wort. St. John’s Wort is a natural herb, SAM-e is a naturally occurring compound found in the human body. While both are used to maintain a healthy mood, a SAM-e supplement is used to replenish naturally occurring SAM-e found in the human body.